The Effects of Suvorexant on Sleep, Stress, and Cue-reactivity in Methamphetamine Use Disorder

The purpose of this study is to determine the effects of SUVO on sleep, stress, and cue reactivity/craving and to evaluate the preliminary safety and side effects profile of suvorexant (SUVO)

Inclusion Criteria:Meet DSM-5 criteria for MA use disorderBe fluent in English and able to understand the consent formExclusion Criteria:Have an alcohol use disorder or report binge drinking (>7 drinks for women and >14 drinks for men)Have a greater than mild substance use disorder on any other illicit substanceHave any medical conditions contraindicating SUVO (e.g., severe pulmonary disease, severe cardiovascular disease or clinically abnormal ECG, severe liver or kidney disease, seizure disorder, or sleep disorder - particularly narcolepsy)Are currently taking medications with known drug interactions with SUVO (e.g., MAO inhibitors, anticonvulsants, haloperidol, phenothiazines, anesthetics, and any sedative)Are pregnant or breast feedingBMI > 30 (women only)Have a current DSM-5 psychiatric disorder or neurological disease requiring on-going treatment that would make participation unsafeHave history of seizure disorderHave a head injury with loss of consciousness in the last 5 years