REALITY MONITORING

Reality-monitoring characterizes the ability to determine whether information was perceived in the environment or only imagined . Impaired reality-monitoring abilities have been associated with hallucinations in patients with schizophrenia and patients with Parkinson's disease.The investigators hypothesize a link between dopaminergic (DA) transmission and reality-monitoring.

Inclusion Criteria:Healthy volunteers who have given their written informed consentMen and women from 18 to 45 years oldNormal or corrected visionBeing fluent in French or French for native languageBeing affiliated with health insuranceExclusion Criteria:Healthy volunteers who have given their written informed consentMen and women from 18 to 45 years oldNormal or corrected visionBeing fluent in French or French for native languageBeing affiliated with health insuranceInadmissibility of the subject's consent or refusalWorking-memory deficit (as controlled with MMSE score< 23)Any past or current psychiatric or somatic condition(as controlled with the Mini International Neuropsychiatric Interview, MINI)Any past or current neurological conditionHistory of cranio-cerebral trauma, arterial hypotension or hypertension, cardiological or serious medical conditionAbnormal potassium dosage (below 3.1 mmol/L or above 4.9 mmol/L)Anormal ECGHistory of schizophrenia or bipolar disorder in first-degree relativesAlcohol-drinking and caffeine intake at least during 24 hours before each sessionDrug therapy excepting contraceptivesCardiologic or severe medical conditioPregnancy(checked with a pregnancy autotest), lactation, or insufficient contraceptive measure (precautionary measure)Consumption of recreational drugs during the last 6 monthsKnown sensitivity to any of the study medication and their excipientsLactose intolerancePorphyriaHepatic insufficiency