Effects of Invasive Mechanical Ventilation on the Right Ventricular Function

The goal of this observational study is to learn about the influence of mechanical ventilation on the right ventricular (RV) function. The primary focus is on methods which are routinely used to improve gas exchange in ventilated patients (positive end expiratory pressure [PEEP], inhalation of NO, prone positioning). The main questions it aims to answer are:Effects of prone positioning, PEEP and inhalation of NO on RV-functionAre there determinants (clinical, laboratory, demographic, echocardiographic) for the right ventricular response to the above?RV-Function will be assessed with right ventricular pressure-volume loops recorded with a conductance catheter ateach PEEP-Level during titration of the best PEEPbefore and every 5 minutes (for max. 45 minutes) after rotation to prone positionbefore and under continuous inhalation of NO (if required based on clinical grounds)

Inclusion Criteria:Age > 18 yearsInvasive mechanical ventilation and clinical indication for prone positioning (e.g. ARDS)No contraindications for right heart catheterization or conductance catheterizationThe written consent of the patient or his legal guardianExclusion Criteria:No written consentcontraindications for right heart catheterization or conductance catheterizationPregnancy or breastfeeding