Role of Mitophagy in Myeloid Cells During Coronary Atherosclerosis.

Atherosclerosis (deposition of a plaque essentially composed of lipids on the artery walls) is a frequent condition and is a leading cause of death worldwide. In addition to the long-established risk factors such as age, hypertension, diabetes or sedentary lifestyle, it has been demonstrated that immune cells can participate in the genesis of atherosclerotic plaques through metabolic and mitochondrial reprogramming.A non-invasive marker of this immune reprogramming has yet to be identified. Through the comparison of a group of atheromatous patients and a group of non-atheromatous patients, this study aims to evaluate this reprogramming phenomenon using a novel non-invasive method.This monocentric interventional study will take place at the Dijon Bourgogne University Hospital and will include 50 patients divided into 2 groups: "atheromatous coronary patients" and "non-atheromatous patients". The duration of participation in this study is 1 month. This study is based on usually performed procedures. Only blood samples will be taken on a catheter usually used during any cardiac surgery in addition to the medical care that is provided during hospitalization.

Inclusion Criteria:- Person who provides oral consentGroup 1:- Patient scheduled for cardiac bypass surgery (isolated procedure) with extracorporeal circulationGroup 2:Patient scheduled for valve surgery with extracorporeal circulationNo coronary lesionNo peripheral arterial disease (limbs, carotids, aortic aneurysm)Exclusion Criteria:Person not affiliated with national health care systemMedication that alters mitochondrial function (Chloroquine, hydroxychloroquine, rapamycin, carbamazepine, resveratrol, sildenafil)Person under a legal protection measure (curatorship, guardianship, tutorship)Pregnant, parturient or breastfeeding womenMajor unable to express consentMinor