Improvement of Memory in Mild Cognitive Impairment

The Clinical Trial will systematically examine the feasibility of remote, caregiver-led tACS for older adults with memory deficits and evaluate whether repeated tACS leads to sustained improvement of neuronal activity and memory functions.

Inclusion Criteria:Mild Cognitive Impairment (MCI) patientsage ≥ 55 years oldclinical diagnosis of mild cognitive impairment (MCI) based on a comprehensive clinical assessment and standard neuropsychological examination including tests of language, visuospatial thinking, executive functions, and memoryconfirmation of diagnosis will be made by Prof. Giovanni Frisoni, the study MD, based on a participant's cognitive evaluation and historyunderstanding of the informed consentable and willing to comply with all study requirementsinformed consent form was signedwomen of childbearing potential (WOCBP) must perform a pregnancy test during screeningCaregiverminimum 21 years of ageself-reported computer/tablet proficiencywillingness to learn how to use tACSavailability during the study period to administer tACS to the participantinformed consent form was signedwomen of childbearing potential (WOCBP) must perform a pregnancy test during screeningExclusion Criteria:Mild Cognitive Impairment (MCI) patientsage < 55 years oldany current diagnosis of a psychiatric disorder (e.g., schizophrenia, bipolar disorder, depressive disorder)other than MCI, any history of other progressive or genetic neurologic disorder (e.g., Parkinson's disease, multiple sclerosis, tubular sclerosis) or acquired neurological disease (e.g., stroke, traumatic brain injury, tumor), including intracranial lesionshistory of head trauma resulting in prolonged loss of consciousnesscurrent history of poorly controlled headaches including chronic medication for migraine preventionhistory of fainting spells of unknown or undetermined etiology that might constitute seizureshistory of seizures, diagnosis of epilepsyany unstable medical condition or chronic uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)contraindication for undergoing MRI or receiving tACSany metal in the brain or skull (excluding dental fillings) or elsewhere in the body unless cleared by the responsible covering MD (e.g., MRI compatible joint replacement)any skin problems, such as dermatitis, psoriasis, or eczemaany electrically, magnetically, or mechanically activated implanted devices such as a pacemaker, intracranial electrodes, implanted defibrillators, medication pumps, nerve stimulators, vascular clips, or any other prosthesis in the brainany serious life-threatening disease such as congestive heart failure, pulmonary obstructive chronic disease, or active neoplasiapregnant womenadults lacking capacity for consentCaregiverinsufficient understanding of study procedurespoor eyesight, severe arthritis in the hands, pain, deformity or other condition that interferes with successful administration of tACS