Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases

The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are:to evaluate the residual neuroplastic processes in DOC state related to music exposureto determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulationto evaluate the impact of this intervention on caregiver's burden and psychological distress.Participants will be randomly assigned to one of three different music-listening intervention groups. Primary outcomes will be clinical, that is based on the neurologist's observations of clinical improvement, and neurophysiological, collected pre-intervention, post-intervention and post-placebo.

Inclusion Criteria:Age > 18 yearsPost-stroke aphasiaPost-stroke neglectPatients with disorders of consciusness (DOC)Exclusion Criteria:No auditory injuryno hystory of neurological diseaseNo hystory of psychiatric diseasePrevious strokeuse of alcohol and drugspremorbid dementia