Retrospective Review of Esophageal Cancer at MSKCC

Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.

Inclusion Criteria:Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomyPathologic staged T3 tumors (pT3)Exclusion Criteria:Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4)Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion,Patients undergoing salvage esophagectomyEvidence of distant metastatic diseasePatients with a positive proximal or distal margin