Metabolomics, Genomics and Nutrition for Cardiovascular Disease Precision Medicine

The objective of this project is to validate, through high-throughput advanced metabolomics techniques, the nutritional assessment tools to be used in the IMPaCT cohort. At the same time, the ability of metabolomics fingerprints of nutritional patterns to discriminate between patients with and without major cardiovascular disease will be identified. Finally, the modification of these predictions will be evaluated based on the genetic profiles. The main hypothesis holds that the integration of metabolomics, genomic and nutritional information will serve to personalize the approach to cardiovascular disease, both in prevention and treatment, and that these tools, in turn, will be valid enough to be applied systematically and efficiently in the IMPaCT cohort.

Inclusion Criteria:Age between 50 - 79 years oldLiving in Spain for more than 2 yearsFluent in SpanishAbility for answer all the study questionaries'Ability to validly grant informed consentAbility to move on one's ownNot under palliative care due to serious illness, institutionalized population will not be recruitedNot planning any change of address to another autonomous community within a year.Receive health care in National Health System. Officials or self-employed workers with health coverage exclusively in "Mutuas" that do not allow telematics access to health data will be excluded.Exclusion Criteria:Chronic alcoholism or regular alcohol consumption > 80 g/dBMI >40 kg/m²Participation in a clinical trial conducted with drugs or use of any drug in experimental status during the year prior to inclusionPatient with cancer treatment two years beforePatient with history of gastrectomy or intestinal resection. Patients with acute infection or inflammatory process (e.g. Pneumonia), may be included in the study three months after the infectious process.