Association Between Periodontitis and the Level of Anti-citrullinated Protein Antibodies in Rheumatoid Arthritis

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 62

Sponsor: Misr International University

Location: Faculty of oral and dental medicine, Misr international university Cairo

Summary

the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics. The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients

Eligibility Criteria

Inclusion Criteria: * Rheumatoid patients fulfilling the ACR criteria for the classification of RA * 18 years * Both genders * Presence of at least 8 teeth Exclusion Criteria: * Smoking * Diabetes Mellitus * Pregnant females * Patients who had undergone periodontal treatment within last 3 months * Antibiotic therapy during last 3 months * Other autoimmune diseases

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05706493). StuddyBuddy aggregates publicly available trial information.