Effectiveness of Outpatient Intravenous Diuretic Therapy for Treatment of Worsening Heart Failure (OUTPATIENT-WHF)

The purpose of the OUTPATIENT-WHF study is to characterize the effectiveness of outpatient intravenous diuretic therapy as a treatment for worsening heart failure.

Inclusion Criteria:≥18 years of agePresentation to a Duke outpatient clinic with heart failure requiring IV diuretics, as per clinician judgementAble to provide signed informed consentSuccessful completion of EuroQOL-5 dimensions surveyExclusion Criteria:Managing clinician without equipoise for initial outpatient treatment strategy versus initial hospitalization-based treatment strategy for heart failure, and decline to accept randomization.Patient without equipoise for initial outpatient treatment strategy versus initial hospitalization-based treatment strategy for heart failure, and decline to accept randomization.History of left ventricular assist device or heart transplantationEnd-stage kidney disease requiring chronic dialysis therapyNew diagnosis of heart failurePregnant or breast-feedingFever >101.0 degrees Fahrenheit at screeningAny other condition that in the judgment of the investigator would jeopardize the patient's compliance with the study protocol