Computerized Cognitive Training to Protect Cognitive Function Among Hypertension Patients

Hypertension is an risk factor for cognitive impairment. The primary objective of this study is to evaluate the efficacy of 12-week computerized cognitive training in people with hypertension and mild cognitive impairment. The researchers will further investigate the long-term effects of cognitive training by prolonging the intervention for 24 weeks among a randomly selected sub-group.

Inclusion Criteria:Older than 60 years;Completed 6 or more years of education;Untreated or under treatment hypertension;Complaint of memory decline within 1 year;Global cognitive score measured by the Montreal Cognitive Assessment is below 26;Agree to receive cognitive function evaluation, randomization, and follow-up investigation as required;Exclusion Criteria:Unable to complete cognitive function evaluation due to vision, hearing, and other problems;Have been diagnosed of dementia or MMSE score ≤ 20;Unable to use the cognitive training equipment after 2 times instructions;Alcohol abuse or taking drugs that could affect cognitive function (antihistamines, antipsychotics);Diabetes patients;Moderate to severe decrease in glomerular filtration rate (eGFR<30 ml/min /1.73m2);Systolic blood pressure ≥180 mmHg or/and diastolic blood pressure ≥110 mmHg; or orthostatic hypotension (defined as the third standing SBP<100mmHg);History of cardiovascular events or hospitalization due to cardiovascular diseases in the last 3 months;Planned to receive coronary intervention, atrial fibrillation ablation or cardiac surgery within 6 months; or have received these intervention strategies in the last 3 months;Symptomatic heart failure or left ventricular ejection fraction <50%；Atrial fibrillation confirmed by ECG with marked and severe onset of symptoms;A history of stroke, or head injury in the last 6 months; past history of brain tumor or neurosurgery;Past history of Parkinson's disease, Alzheimer's disease, schizophrenia, and epilepsy;Have Ever undergone surgery under general anesthesia in the last three months;Severe hepatic impairment or in critical condition patients with very poor prognosis whose expected survival is less than 6 months; or diagnosed of malignant tumor other than non-melanoma skin cancer in the last 2 years;Contradictions for MRI examination: such as metal implantation, claustrophobia, etc.;Unable to obtain an informed consent or currently taking part in other clinical trials