Effect of Exercise on Disease Activity in Patients With Ankylosing Spondylitis by SIRI and SII

The systemic inflammatory response index (SIRI) is defined as "neutrophil count × monocytes/lymphocyte counts". It has been reported that SIRI can predict survival in various types of cancer, including pancreatic cancer , gallbladder cancer , oral squamous cell carcinoma , and cervical cancer. Again, SIRI can demonstrate disease activity in patients with rheumatoid arthritis (RA), It has been reported that it can predict the development of RA-related interstitial lung disease and tumor development .Ankylosing spondylitis management strategies should be aimed at controlling disease activity, improving spinal mobility and functional status . Treatment usually includes the use of anti-inflammatory drugs to reduce pain and stiffness, and the use of disease-modifying drugs to try to stop or prevent disease progression. Patients are also advised to exercise to maintain the mobility of the spine and peripheral joints . Studies on this subject reveal that exercise is as important as drug therapy in the treatment of AS . Again, the importance of exercise in AS was emphasized in the clinical guidelines for the treatment of AS by ASAS (The Assesment in Ankylosing Spondylitis : Working Group) and EULAR (European League Against Rheumatism) . In addition to the effects of exercise on muscle strength, joint limitations, physical performance, endurance capacity and quality of life, its anti-inflammatory effects are also known.In this study, it was aimed to evaluate the effect of exercise therapy on disease activity in AS patients with systemic inflammatory response index (SIRI) and systemic inflammation index (SII). There is not enough evidence in the literature that systemic inflammatory response index (SIRI) and systemic inflammation index (SII) can be used in the evaluation of disease activity in AS.

Inclusion Criteria:Being diagnosed with ankylosing spondylitis according to the modified New York criteria and/or ASAS criteriaExclusion Criteria:Presence of neurological disease (Epilepsy, stroke, Parkinson's, etc.) Severe cardiac disease (coronary artery disease, history of myocardial infarction and angina, heart failure) Pacemaker users Patients with COPD and advanced respiratory failure Hypertension and diabetes that cannot be controlled with medication malignancy Acute or chronic infections Organ/System dysfunction History of previous upper and lower extremity orthopedic surgery Patients with joint prosthesis Insufficient cooperation Pregnancy Cognitive dysfunction Dementia Presence of psychiatric illness