Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

The goal of this clinical trial is to test titrated oxygen in prehospital patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The main question it aims to answer is:To determine whether prehospital titrated oxygen strategy in patients with suspected AECOPD will decrease 30-day mortality compared to patients receiving standard care.Participants in the intervention will receive titrated oxygen - a mix of supplemental oxygen and compressed atmospheric air as driver for inhaled bronchodilators to target SpO2 (oxygen saturation) 88-92%. The intervention will be compared to standard treatment, using compressed oxygen (100%) as driver for inhaled bronchodilators.

Inclusion Criteria:Patients over the age of 40EMT or Paramedic suspected AECOPDConfirmed suspicion of COPDExclusion Criteria:Bronchospasm due to asthma, allergic reaction or non-COPD conditionsKnown or suspected pregnancyPrehospital Non-invasive, invasive or assisted bag mask ventilationAllergy to inhaled bronchodilators (Salbutamol)Inter-hospital transferMore than 2 doses (5 mg salbutamol) inhalation drug, acute treatment by EMS (emergency medical service) personnel, before allocated treatment is initiatedSuspicion of acute coronary syndrome