Transplantation of Uncontrolled DCD Kidneys REconditioned by a Novel Ex-VIVo Perfusion MEthod

Eight patient will be transplanted with kidneys from donors dying after uncontrolled circulatory arrest (uDCD), with prolonged warm ischemia (up to 4,5 hours), preserved by a new method based on removal of fibrinogen/fibrin in the capillary systems, leading to an effective oxygenation of the tissue using an ex-vivo hospital manufactured perfusion device, minimizing the risk for ischemia-reperfusion injury (I/R-I) after kidney transplantation.Each patient will be studied for three months, with long-term follow-up data collected at 6 and 12 months

Inclusion Criteria:Both sexesAge 18 - 65First-time transplantABO blood-group identicalLiving within 4 hours from transplant siteWritten consentExclusion Criteria:Human Leukocyte Antigen (HLA) antibodies and/or preformed donor specific antibodies (DSA)Total ischemia time of > 16 hoursMulti organ transplant recipients or previously transplantedABO-incompatible or positive complement-dependent crossmatch (CDC X-match)Contraindicating medical conditionContraindicating malignancyRecent drug abuseNon-adherent or difficulties understanding the protocolKnown risk factors for technical surgical complications (i.e. serious arteriosclerosis and or obesity)