Fluid Agitation Microbiologic Yield In Pleural Infection Feasibility Study

The goal of this study is to compare the microbiologic diagnostic yield of pre-aspiration agitated pleural fluid versus that of conventionally aspirated fluid in pleural infection patients. The main question it aims to answer is, whether fluid agitation helps to increase the microbiological yield.

Inclusion Criteria:Age >18 years oldPleural infection based on clinical presentation, imaging or laboratory investigations and pleural fluid examination showing glucose < 40 mg/dL or pH <7.2 with lower respiratory infection or pus on aspirationAt least a moderate amount of pleural fluid collection (2 or more intercostal spaces on thoracic ultrasound)Exclusion Criteria:Minimal - mild pleural fluid deemed unsuitable for aspiration and agitationHemodynamic instabilityUncorrected coagulopathyTransudative or exudative lymphocytic pleural effusion on biochemical analysis