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Completed
NCT05701202
Assessing the Impact of "Super-whey" vs. Isonitrogenous Whey on Muscle Protein Synthesis
Conditions: Sarcopenia
Sex: Male
Ages: 18 Years – 85 Years
Healthy volunteers: 1
Phase: NA
Enrollment: 20
Sponsor: University of Nottingham
Location: United Kingdom
Summary
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
Undesirable loss of skeletal muscle mass (atrophy) is, however, a common feature of many diseases and scenarios including ageing, bed rest/immobilisation, cancer and physical inactivity.
Despite the exact mechanisms causing muscle atrophy being not yet fully understood, "anabolic resistance" (reduced muscle building in response to protein feeding and exercise) is thought to be key, especially for age-related skeletal muscle losses (known as sarcopenia).
As such, the search for optimal strategies (e.g., exercise and/ or nutritional interventions) to combat this anabolic blunting remains a hot-topic in scientific research.Leucine, an essential and branched chain amino acid (EAA/BCAA), is thought to be the most potent AA for stimulating muscle protein synthesis (MPS; the muscle building process).
Although, as a stand-alone supplement, leucine is unlikely to provoke a robust and prolonged state of MPS, low doses of leucine-enriched mixed-EAAs can elicit similar increases in MPS as compared to a large dose of whey protein.
As reduced appetite and increased satiety (feeling fuller) are common with advancing age, supplementation of a low-dose protein (i.e., leucine-enriched) that can adequately stimulate MPS may contribute to muscle health maintenance in older adults and reduce satiation following a meal.This study aims to examine whether a novel whey protein with greater leucine content ("super-whey") has superior muscle building properties compared to a regular whey protein, at rest and after a single bout of exercise, in both young and older adults
Eligibility Criteria
Inclusion Criteria:Participant is in the desired age-ranges (young adults: 18-35 years; older adults: 65+ years).Participant is willing and able to give informed consent for participation in the study.Participant is physically able to perform resistance exerciseExclusion Criteria:A BMI <18 or >35 kg/m2Active cardiovascular, cerebrovascular or respiratory disease: e.g.
uncontrolled hypertension (BP > 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent (6 mo) strokeAny metabolic diseaseClotting dysfunctionA history of, or current neurological or musculoskeletal conditions (e.g.
epilepsy)Lactose intoleranceHaving taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Source: ClinicalTrials.gov (NCT05701202). StuddyBuddy aggregates publicly available trial information.
