Refining Cough Skill Training in Parkinson's Disease and Dysphagia

Airway protection deficits (cough and swallowing) are prevalent and pervasive in Parkinson's disease (PD), contributing to adverse health outcomes like pneumonia. This study aims to refine cough skill training by examining whether variable versus constant practice conditions improve cough outcomes in people with PD. In addition, this study will provide insight into optimal respiratory adaptations that occur during training to support cough effectiveness, resulting in immediately translatable treatments to improve airway protection-related health outcomes in people with neurodegenerative disease.

Inclusion criteria:40 years of age or olderhave dysphagia as documented by a penetration-aspiration score > 2 on a flexible endoscopic evaluation of swallowinghave cough disorder as defined as a maximal voluntary cough peak flow < 5 L/shave no history of other neurological disorders, head and neck cancer, respiratory disease, smoking within 5 years, uncontrolled hypertension, or allergy to capsaicin (reflex cough stimulus)Exclusion criteria:unable to participate due to neuropsychological dysfunction (i.e., dementia with a score of < 19 on the Montreal Cognitive Assessment)actively participating in other cough or swallowing treatments