The Relationship Between Myonectin Concentration and the Course of ST-segment Elevation Myocardial Infarction

The aim of this study is to test the potentially protective role of myonectin in patients with a first episode of ST elevation myocardial infarction (MI) treated with primary percutaneous coronary intervention (PCI).The main questions which are assumed to be answered after study completion:Does higher myonectin concentration influence the in-hospital and 30-day course of the first ST-elevation MI in patients treated with primary coronary angioplastyIs there a relationship between the serum myonectin concentration, related to patient's nutritional status and physical activity with the patient's physical activity declared as usually before the coronary event occurrence, the cardiac biomarkers level, and myocardial and skeletal muscle mass determined in order to objectify the relationship of physical activity before the infarction with 30-day and one-year mortality, and the other primary and secondary outcomes measured at 12-month visit, e.g. the extent of myocardial infarction,Is there a relationship between the baseline concentration of myonectin and troponin with the control of atherosclerosis risk factors, declared physical activity and parameters of body composition, outcome of treadmill exercise test, values of echocardiographic parameters and myonectin concentration 12 months after a cardiovascular incident

Inclusion Criteria:symptoms of acute coronary syndromeacute ST segment elevation in two or more leads in ECGprimary PCIExclusion Criteria:pregnancypatients unconscious, with altered consciousness or not able to cooperatecardiogenic shocksignificant physical effort within 24 hours before onset of MIactive infection at admission, intramuscular injectionmyocardial infarction in patient's medical historyheart failure New York Heart Association (NYHA) class III - IV in patient's medical historyrenal failure (chronic kidney disease, CKD) with glomerular filtration rate (GFR) < 30ml/minhistory of malignant neoplasms in the last 5 yearspatients incapacitated, active soldiers, imprisoned or related with investigators