Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO

Conditions: Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia, Oxygen Delivery

Sex: All

Ages: 18 Years – N/A

Phase: PHASE1

Enrollment: 238

Sponsor: University Hospital, Lille

Summary

This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.An individualized transfusion strategy based on ScVO2 level, is compared to a conventionnal strategy based on predefined hemoglobin threshold. The primary endpoint is the consumption of packed red blod cells, secondary endpoints are subgroup analysis, mortality, morbidity, and cost-effectiveness

Eligibility Criteria

Inclusion Criteria:Age of 18 and older,supported by peripheral VA-ECMOfor cardiogenic shockLife expentency >90 daysCentral venous line available ScVO2 measurementExclusion Criteria:Pregnancy,Lack of health insurance,Opposition to blood transfusion,Known congenital hemoglobin disease or disorder,Metabolic alcaloosis with pH>7.8,eCPR,Legally incapacitated adults

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05699005). StuddyBuddy aggregates publicly available trial information.