Validation of vFFR as Compared to FFR to Guide Revascularization of Non-culprit Lesions in STEMI Patients

This prospective multicenter observational cohort study is designed to study the diagnostic performance of acute-setting angiography-based FFR (e.g. vFFR) for the physiological assessment of intermediate non-culprit lesions in STEMI patients, with acute-setting FFR and acute-setting NHPR (e.g. RFR) as the reference standards.

Inclusion Criteria:18 years or older.At least one intermediate non-culprit lesion (50-90% diameter stenosis by visual estimation or online QCA) in a non-infarct related artery (reference vessel diameter >2.00 mm) for which invasive pressure wire-based physiological assessment is deemed feasible and indicated.Exclusion Criteria:Presentation with cardiac arrest or cardiogenic shock.Previous coronary artery bypass graft surgery or percutaneous coronary intervention involving the non-culprit vessel.Ostial left main or ostial right coronary artery lesion.Excessive overlap, foreshortening or tortuosity precluding vFFR computation.