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Completed
NCT05698342
Tissue-resident Memory T Cells Expression in Melasma
Conditions: Melasma
Sex: Female
Enrollment: 20
Sponsor: Universidad Autonoma de San Luis Potosí
Location: Mexico
Summary
The treatment of melasma and the maintenance of depigmentation represent a challenge due to its frequent recurrences.
Pathophysiological mechanisms and factors have been linked to melasma such as inflammation, sun exposure, increased CD4+ T lymphocytic infiltrate and IL-17 in damaged skin.
Tissue-resident memory T cells (Trm), derived from naïve T lymphocytes, are associated with the recurrence of lesions at the same sites but they have not been described in melasma.
This a Cross-sectional, prospective analytical study.
20 female patients, 18 to 55 years of age, with diagnosis of melasma and mMASI score of at least 7, at least 1-year duration, lesional and perilesional skin biopsies were taken for PCR and DIF.
The objective is to determine the transcription factors of Trm cells in malar melasma.
Eligibility Criteria
Inclusion Criteria:female patients with malar melasma, healthy volunteers 18 years of age and older, without previous treatment or photoprotection measures within the previous 4 weeks, who had at least 7 Modified Melasma Activity and Severity Index (mMASI) scoreExclusion Criteria:Exclusion criteria were pregnancy or nursing, menopause, coexistence of other pigmentation conditions, heat exposure, regular exer- cise, diet restriction, consumption of food supplements or any type of drugs (including anti-inflammatories and hormonal treatments) within the previous 2 months, and women who had given birth within 1 year
Source: ClinicalTrials.gov (NCT05698342). StuddyBuddy aggregates publicly available trial information.
