Impact of the Depth of Neuromuscular Blockade on Respiratory... | Clinical Trial | StuddyBuddy@endsection Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients
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Completed NCT05697666

Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients

Conditions: Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury

Sex: All
Ages: 18 Years – N/A
Enrollment: 33
Sponsor: Centre Hospitalier de Saint-Brieuc

Location: France

Summary

Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory mechanics by reducing ventilator induced lung injuries (VILI), especially the so called atelectrauma. Although its monitoring is recommended in clinical practice, data about the depth of NMB necessary for an effective relaxation of the thoracic and diaphragmatic muscles and, therefore, the reduction of the chest wall elastance, are scarce. The investigators hypothesised that complete versus partial NMB can modify respiratory mechanics and its partitioning.

Eligibility Criteria

Inclusion Criteria:Moderate to severe ARDS patients with PaO2/FiO2 ratio < 150 mmHgMechanical ventilation, deep sedation and neuromuscular blockade with continuous infusion of cisatracurium for more than 24 hoursPresence of an oesophageal catheterWritten informed consentExclusion Criteria:contraindication of oesophageal catheter

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05697666). StuddyBuddy aggregates publicly available trial information.