Preterm Neonates Brain Ultrasound With CEUS and Elastography

Sex: All

Ages: 3 Weeks – 6 Months

Phase: PHASE3

Enrollment: 100

Sponsor: Turku University Hospital

Summary

The aim of the study is to investigate levels of brain perfusion and elasticity in preterm neonates when they reach the estimated due date and to compare the data with magnetic resonance imaging at term. Contrast enhanced ultrasound (sulphur hexafluoride) and ultrasound-assisted elastography will be used to evaluate the state of brain perfusion with ultrasound. Different appropriate imaging sequences will be used regarding MRI, including asl-perfusion. Neonates recruited from the Neonatal Intensive Care Unit (NICU) of Turku University Hospital will be recruited.

Eligibility Criteria

Inclusion Criteria:Preterm neonates attending brain MR-imaging at termExclusion Criteria:Pre-known genetic diseaseDifficult congenital malformations that need surgical treatmentCentral nervous system tumorsWeight less than 2,5 kg during examinationMedical history of SonoVue hypersensitivityUncontrolled systemic hypertensionSystolic pulmonary artery pressure > 90 mmHgUnstable cardiovascular state

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05694611). StuddyBuddy aggregates publicly available trial information.