Augmenting Single-session Behavioral Activation (BA) With Delta-beta Transcranial Alternating Current Stimulation (tACS) for the Treatment of Depression

Investigating whether delta-beta cross-frequency transcranial alternating current stimulation can augment the effects of a single session of behavioral activation in participants with major depressive disorder.

Inclusion Criteria:18 years old or orderAble to provide informed consentWilling to comply with all study procedures and be available for the duration of the studySpeak and understand EnglishDSM-5 diagnosis of major depressive disorder (MDD) as assessed by the MINIExclusion Criteria:Participants must not have active suicide intent as determined by the Columbia Suicide Severity Rating Scale (C-SSRS). Active suicide intent will be captured in responses to items 4 and/or 5 on the C-SSRS.Participants must not meet criteria for current severe substance use disorder, anorexia nervosa, or active psychosis as captured by the MINI.Participants may not currently be in psychotherapy and have not received any other psychotherapy and/or stimulation (ECT, TMS) within the last 4 weeks.Any participants taking psychotropic medication must be on a stable dose for at least 4 weeks with no planned dose changes within the next 4 weeks.(for female participants) Participants must not be pregnant or breastfeeding.Participants may not have any medical or neurological illness for which symptom presentation or treatment could interfere with study participationParticipants may not have undergone prior brain surgeryParticipants may not have any brain devices/implants, including cochlear implants and aneurysm clipsParticipants may not have had brain injury or concussion within the last three monthsParticipants may not have a history of brain injury requiring current treatment