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NCT05692245
Dexamethasone vs Ondansetron After Cesarean Delivery
Conditions: Nausea and Vomiting, Postoperative, Cesarean Section Complications, Spinal Epidrual
Sex: Female
Ages: 18 Years – 45 Years
Phase: PHASE4
Enrollment: 100
Sponsor: Beth Israel Deaconess Medical Center
Location: United States
Summary
The goal of this clinical trial is to compare medications in women having a cesarean delivery.
The main question it aims to answer are:• Which medication is better to use as a first-line prevention agent for nausea and vomiting Participants will rate their nausea, pain and other symptoms after surgery Researchers will compare two drugs, ondansetron and dexamethasone to see if the side effects of pain medications are improved after cesarean.
Eligibility Criteria
Inclusion Criteria:Healthy women (ASA 2)Between 18 and 45 years oldSingleton term pregnanciesScheduled or non-labor cesarean deliveryNeuraxial (spinal or combined-spinal epidural) anesthesiaExclusion Criteria:Refusal to participateKnown allergy or contraindication to any medication used in the studySignificant medical or obstetrical disease (ASA ≥ 3)Antiemetic use within 24 hours preceding cesarean deliveryInsulin dependent diabetesHyperemesis gravidarum or chronic antiemetic useHistory of daily or near-daily steroid use during pregnancyOpioid use disorder or other chronic pain syndromeOpioid use during pregnancyUse of antipruritus medication, pruritic urticarial papules of pregnancy, or cholestasis of pregnancy
Source: ClinicalTrials.gov (NCT05692245). StuddyBuddy aggregates publicly available trial information.