Cognitive Reserve-building Activities in Multiple Sclerosis

The study is a crossover randomized controlled trial investigating the effect of increasing engagement in cognitive leisure activities on objective and subjective measures of cognition in individuals with multiple sclerosis.

Inclusion Criteria:RRMS, SPMS or PPMSAge 18-65EDSS score ≤ 6.5SDMT (or PASAT) score below -1 SDNo depression based on the MDIAble to use computer or smartphone and has internet accessIf in treatment with one or more of the following medications, the dosage must be stable:CannabinoidsAnticholinergic medicationsSedatives e.g., benzodiazepinesOpioidsAntispasmodicsBeta-blockersAntidepressant medicationFampridineExclusion Criteria:Planned start-up or discontinuation of one or more of the above-mentioned medicationsStructural brain changes following previous head trauma or neurological conditions other than which lead to structural changes or affect cognitive abilitiesEpilepsySignificant psychiatric co-morbiditySignificant somatic co-morbidity including, but not limited to, severe cardiovascular disease as well as liver, kidney, and endocrine diseasesRelapse 3 months prior to inclusion