Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium

In population of intensive care unit (ICU), most studies compared atypical antipsychotics such as quetiapine with the traditional haloperidol in delirious patients of various forms and etiologies. The role of such agents in patients with hyperactive is not fully understood.This study compares the effectiveness of quetiapine with haloperidol in treating the hyperactive form of delirium in terms of their effects on morbidity, length of stay in the intensive care unit, and mortality in critically ill patients.

Inclusion Criteria:All patients who are diagnosed with hyperactive form of delirium during their ICU stay using CAM-ICU tool (the confusion assessment method for the intensive care unit)Exclusion Criteria:Suspected substance-induced deliriumPrevious use of antipsychoticsKnown allergy or intolerance to the study drugsPregnancy or breast feedingAcute renal injuryHepatic failureInability to tolerate oral drugs