Lidocaine Infusion on Optic Nerve Sheath Diameter in Laparoscopic Hysterectomy in Trendelenburg Position

We hypothesize that intravenous lidocaine infusion may have beneficial effect to patients undergoing laparoscopic surgeries in Trendelenburg position by preventing ICP elevation.

Inclusion Criteria:Aged between 35 to 65 yearsAmerican society of anesthesiology (ASA) physical status I - IIBody mass index (BMI) between 18.5 to 28.0 kg/m2Scheduled for total laparoscopic hysterectomy taking approximately 2 h with a 30° Trendelenburg position for management of uterine fibroids or refractory dysfunctional uterine bleeding.Exclusion Criteria:Patients with eye diseases, central nervous system diseases, cardiovascular diseases, cerebrovascular diseases or diabetes.If these events occurred intraoperative:Ultrasound scans or measurements failed to clearly show the structure of Optic Nerve Sheath Diameter (ONSD).Surgical time less than 1 h.Interruption of carbon dioxide (CO2) pneumoperitoneum and Trendelenburg position.Peak airway pressure exceeding 35 cm H2OPatients with a history of allergy to lidocaine.