Preemptive and Preventive Acetaminophen/Ibuprofen Fixed-dose Combination After Robot-assisted Radical Prostatectomy

This prospective, randomized, double-blinded study is designed to compare opioid-sparing effect of preemptive and preventive intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing robot-assisted radical prostatectomy (RARP). We hypothesize that preemptive administration of intravenous acetaminophen/ibuprofen fixed-dose combination can significantly reduce postoperative opioid consumption and pain severity than preventive administration in patients undergoing RARP.

Inclusion Criteria:Patients scheduled to undergo elective robot-assisted radical prostatectomy under general anesthesiaAmerican Society of Anesthesiologists (ASA) physical classification I-IIConsent to IV-patient controlled analgesia useWillingness and ability to sign an informed consent documentExclusion Criteria:Who do not understand or agree with our studyAmerican Society of Anesthesiologists (ASA) physical classification III-IVChronic usage of opioid analgesicsModerate to severe pain with other cause before surgeryAllergies to anesthetic or analgesic medications used in this studyAnticipated blood loss larger than 2 litersNeed for intensive care after surgeryHistory of gastric ulcer or gastrointestinal bleedingHistory of liver failure, renal failure or heart failureCurrent alcoholismTaking anti-coagulation drugs or history of coagulation diseaseHistory of bronchial asthmaMedical or psychological disease that can affect the treatment responseTaking barbitutate or tricyclic antidepressant