The Effect of a Fast-mimicking Diet on Periodontal Treatment

The aim of the present study is to test if a fasting mimicking diet (FMD) can influence the systemic and periodontal response following non-surgical periodontal therapy. The null hypothesis is that a FMD does not modify the local and systemic inflammatory post-treatment response.The test group will have periodontal treatment followed by fasting mimicking diet while the control group will have the same periodontal treatment and continue with their normal diet.Full-mouth clinical periodontal measurements including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI) and plaque index (PI) will be recorded.Blood and GCF samples will be taken.Enzyme-linked immunosorbent assay (ELISA) will be used to determine biochemical parameters in the biological samples.

Inclusion Criteria:18-70 years old patientsPeriodontitis stage III-IV, grade B-CSystemically healthyNormal weight to overweight. Body mass index: 18-30Minimum of 24 teeth presentBe willing and physically able to carry out all study procedures.Absence of hopeless teeth, acute dental conditions, teeth with endo-periodontal lesions and necrotising periodontal diseases.Exclusion Criteria:Age> 70 years oldSmokersSystemically compromisedUnderweight/ObesePregnantAlcoholismSystemic antibiotics intake within 3 monthsPeriodontal treatment in the last 12 monthsMental illness, depression, dementia.Denture wearer/ presence of dental implantsUnable or unwilling to participate in baseline or follow up examinationsUnable or unwilling to complete the dietary interventionSignificant food allergies