Optimization of Serum Phosphorus Level and Weaning From Mechanical Ventilation

The goal of this clinical trial is to test the impact of serum phosphorus level optimization on weaning from mechanical ventilation in adult ICU patients in Alexandria University Hospitals.The main questions it aims to answer are:Does serum phosphorus level optimization affect the duration of mechanical ventilation?Is serum phosphorus level optimization associated with successful weaning from mechanical ventilation?In critically ill patients, phosphorus supplementation is done using Sodium glycerophosphate pentahydrate solution.

Inclusion Criteria:Adult mechanically ventilated ICU patients.Age ≥ 18 years.Exclusion Criteria:Age <18 yearsHypernatremiaPermanent or prolonged mechanical ventilationHyperphosphatemia which might occur in the following conditions:Chronic kidney disease and end stage renal diseaseParathyroid disordersCancer patients at risk of tumor lysis syndromeImmobilityBody weight < 50 Kg