Metabolic and Inflammatory Outcomes of the Ketogenic Diet Comparing Saturated and Unsaturated Fat Sources

The goal of this clinical trial is to compare a healthy KETO diet supplemented with canola oil (KETO-Can) compared to a traditional KETO diet high in saturated fat (KETO-Sat) and low-fat diet (LFD) in adults at high risk of or diagnosed with type 2 diabetes. The main question[s] it aims to answer are:Effects on CVD risk factors (plasma cholesterol, TG, ApoB100, glucose, insulin and HbA1C).Effects on systemic inflammation and immune function.Safety and adherence to interventions.Participants will be randomized into 1 of the dietary treatments during which they will follow a Keto or a low-fat diet.Comparisons among groups at 3 and 6 months of intervention will be conducted.

Inclusion Criteria:Having overweight or obesity and HbA1C ≥ 5.7% at screeningExclusion Criteria:Individuals with specific nutritional habits preventing them from adhering to nutritional recommendationspregnant womenpeople on dialysis or recommended to follow a low-protein diet (base on glomerular filtration rate)familial hypercholesterolemia or hypertriglyceridemiatransitioning trans-gendertransitioning menopausal women.