microRNAs in the Diagnosis of Atherosclerotic Plaque Instability

It's a non-randomized, intervention, prospective, single-center study.The aim of the work is to identify of biomarkers of unstable atherosclerosis in brachiocephalic arteriesTasks:identify microRNAs, the expression of which is characteristic of unstable atherosclerotic lesions;to assess the relationship of miRNA and trimethylamine N-oxide with the progression of unstable atherosclerotic lesions;to determine the effect of the level of plasma trimethylamine N-oxide on the progression of atherosclerotic lesions.

Inclusion Criteria:Availability of written informed consent to participate in research work;Age from 18 to 85 years;Availability of data from a general blood test, blood lipid profile (total cholesterol, very low density lipoproteins, low density lipoproteins, high density lipoproteins, triglycerides);Absence of clinical signs of atherosclerosis of brachiocephalic arteries (no stroke, transient ischemic attack. On auscultation of the carotid arteries, there are no additional noises);Absence of signs of atherosclerosis of the brachiocephalic arteries according to ultrasound duplex scanning (USDS) and/or multispiral computed tomography (MSCT) angiography of the brachiocephalic arteries;Conducted outpatient visit at a research center with clinical and biochemical blood tests performed, ultrasound examination of arterial vessels and/or multispiral tomography of arterial vessels with contrast enhancement and/or hospitalization at a research center.Non-inclusion criteria:Chronic kidney disease stage 3b and above (glomerular filtration rate < 45 ml / min / 1.73 sq.m);The presence of severe somatic pathology (with the exception of atherosclerosis of the carotid arteries and conditions caused by it), reducing life expectancy to less than 6 months;Chronic somatic diseases in the acute stage;Weight less than 40kg and more than 125kg;Pregnancy.Exclusion Criteria1. Refusal to continue participation in the study.