How Effective is the Dose-graded Aerobic Training in Children Survivors of Acute Lymphoblastic Leukemia?

The purpose of this study was to evaluate the impact of a 12-week dose-graded aerobic exercise program (D-GAE) on cardiopulmonary fitness and physical performance in children survivors of acute lymphoblastic leukemia (ALL). A total of 58 ALL survivors were randomly assigned to the D-GAE group (n = 29, who underwent a combination of traditional physical rehabilitation and intensity- and duration-graded aerobic training three times per week for 12 weeks) or the control group (n = 29, who underwent only traditional physical rehabilitation).Cardiopulmonary fitness and physical performance were evaluated in both groups before and after treatment.

Inclusion Criteria:Survivors of childhood ALLAge of 10-18 yearsCompletion of maintenance therapyFree of lower limb or spinal deformitiesNot participating in regular exercise regimens in the past six monthsExclusion Criteria:Secondary malignanciesSignificant musculoskeletal/neurological issuesNeurocognitive impairments