Biological Signatures Resulting From Occupational Exposure to Complex Mixtures of PAHs

This research project aims at better understanding the early biological effects resulting from occupational exposure to complex Polycyclic Aromatic Hydrocarbon (PAH) mixtures.Current biomarkers used as part of biomonitoring campaigns are biomarkers of exposure, not numerous and poorly related to health effects.The aim of this study is thus to improve our understanding of biological consequences of such exposures, both in terms of proteins deregulation, metabolism deregulation and genotoxicity.

Inclusion Criteria:Subjects ages 18 years or moreSubjects occupationally exposed to PAHs since more than 3 monthsHaving signed the informed consentrecruited by the occupational health serviceExclusion Criteria:Obesity (BMI>30)Subjects suffering cancers or metabolic diseases (diabetes, dyslipidemia, amino-acid diseases, renal or hepatic impairment) at the onset of the study.Subjects taking medications related to the above diseases at the onset of the study.