Structural and Functional Grey and White Matter Changes in Patients With Pain Disorders

The goal of this observational study is to examine the association between exact lesion location and presence of thalamic CPSP (Central post-stroke pain) in a larger number of patients after thalamic stroke.

Inclusion Criteria:Patients with thalamic central post-stroke pain (CPSP) :Patients fulfilling all of the following inclusion criteria are eligible for the study:Informed Consent as documented by signature (Appendix Informed Consent Form)History of thalamic stroke (infarction or bleed)Diagnosis of definite central-post stroke pain (according to the criteria proposed by Klit et al, 2009)No other chronic pain conditionAge: ≥18 years oldPatients with thalamic stroke without CPSP:Patients fulfilling all of the following inclusion criteria are eligible for the study:Informed Consent as documented by signature (Appendix Informed Consent Form)History of thalamic stroke (infarction or bleed), at least 2 years agoNo chronic pain condition (neither CPSP or other pain condition)Age ≥18 years oldPatients with migraine (other pain condition):Patients fulfilling all of the following inclusion criteria are eligible for the study:Informed Consent as documented by signature (Appendix Informed Consent Form)History of highly frequent (≥8 monthly migraine days) or chronic migraine (≥15 monthly migraine days).No history of strokeAge ≥18 years oldHealthy controls:Participants fulfilling all of the following inclusion criteria are eligible for the study:Informed Consent as documented by signature (Appendix Informed Consent Form)No history of strokeNo chronic pain conditionAge: ≥18 years oldExclusion Criteria:History of severe neurological, internistic or psychiatric diseaseMRI related exclusion criteria:paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the brain)PacemakerClaustrophobiaPregnancy