Role of Paclitaxel in Stricture Urethra

Stricture urethra is a common disease and has various causing factors. The most common performed procedure is direct visual internal urethrotomy (DVIU), but unfortunately has a high recurrence rates. Multiple trial were performed to improve the outcomes of DVIU. Various intralesional injections were used. in this trial we will evaluate intralesional paclitaxel injection following DVIU.

Inclusion Criteria:Anterior urethral strictureShort strictures (less than 2 cm)International Prostate Symptom Score less than 11 and maximum flow rate < 15 ml per second.No previous treatment for stricture diseaseExclusion Criteria:Recurrent casesPrior pelvic radiationAssociated other pathology or unresolved confounding etiologies (e.g. bladder neck contracture, neurogenic bladder, benign prostatic hyperplasia) were excluded.