Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-III)

The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis strategies for the prevention of surgical site infections.

Inclusion Criteria:Healthy male and female participants ≥ 18 years who volunteer for the pilot study, in which a routine photodynamic treatment at the Department of Dermatology will be performed and effect of skin colonization will be analyzed, and who signed an informed consent (after information about the project)Exclusion Criteria:Pregnant and lacting womenParticipants with inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.,Participants taking antibiotics in the 14 days prior to PDT or until follow-up at 21 daysParticipants who received oral retinoid therapy within the last 6 monthsParticipants who received anti-inflammatory agents as NSAR within the 14 days prior and after the PDTParticipants taking any photosensitizing drugs within 4 weeks prior to PDTParticipants who had a history of photosensitivity disorderFitzpatrick's skin phototype V-VI