Effects on Ventilation With NHF and Asymmetrical Nasal Cannulas

The aim of this controlled randomized crossover study is to compare the physiological effects of nasal high flow therapy (NHF) with 2 different nasal cannulas in patients with exacerbated chronic obstructive pulmonary disease (ECOPD) and chronic respiratory failure.20 patients will be treated with NHF therapy (Airvo, Fisher&Paykel Healthcare, NZ) during wakefulness. Physiological measuremends will take place over three perdiods (visits). One period without NHF, one with NHF via standard cannula (Optiflow M) and one with asymmetrical cannula (Optiflow Duet) in randomised order.

Inclusion Criteria:Inpatients with COPD GOLD 3 and 4 in stable phase after acute exacerbationInpatients with COPD GOLD (2, 3 and 4)Informed ConsentExclusion Criteria:Acute respiratory insuffiency with respiratory acidosis (pH<7.35)Severe acute physical disease, that do not allow the subject to participate in a clinical trialLanguage, cognitive, or other barriers that make study participation impossiblePregnancy or Nursing