Study of Microvesicles in Pre-eclampsia

A large number of studies on MVs from syncytiotrophoblasts support the hypothesis of their involvement in pre-eclampsia, via their multiple effects, among others as pro-coagulant, immuno-stimulatory and anti-angiogenic factors.The main objective is to compare the total concentration of the main populations of MVs in the maternal blood of a population of pre-eclamptic patients to those of a population of non-pre-eclamptic patients.

Inclusion Criteria:Age ≥ 18 yearsSingleton pregnancy (or spontaneously reduced twin pregnancy before 14 SA)Gestational age at inclusion between 23 and 31+6 SACollection of the patient's non-oppositionAffiliated or beneficiary of a social security systemSpecifically for the non-pre-eclampsia group: non-pre-eclamptic patient hospitalized for a threat of preterm delivery, whatever the origin, and without clinical or biological markers of inflammationSpecifically for the pre-eclampsia group : diagnosis of severe pre-eclampsia before 32 weeks' gestationExclusion Criteria:Patient's inability to understand the nature, risks, meaning and implications of the clinical investigation or refusal to give consentPatient under legal protection.