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Recruiting
NCT05672030
Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
Conditions: Nasal Polyps, Aspirin-exacerbated Respiratory Disease
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: 1
Enrollment: 30
Sponsor: Brigham and Women's Hospital
Location: United States
Summary
The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.
Eligibility Criteria
Inclusion Criteria:AERD, CRSwNP, healthy controlsExclusion Criteria:Not on any systemic steroids or respiratory biologics at time of surgery
Source: ClinicalTrials.gov (NCT05672030). StuddyBuddy aggregates publicly available trial information.
