Electroclinical Correlates in Essential Tremor

Essential tremor (ET) is a neurological disorder that affects nearly 0.9% of the world's population. High-frequency Deep Brain Stimulation (DBS) of the ventral-intermediate nuclei of the thalamus (VIM) has been proven as an effective second-line treatment for severe forms of ET.The arrival on the market of the PERCEPT™ (new stimulator/recorder, Medtronic, Minneapolis, USA) now allows, in addition to the stimulation delivery, the recording of intracerebral activity at a distance from surgery, in a non-invasive way and in ecological condition at home. Investigators aim at recording the variations of thalamic Local Field Potentials (LFP) oscillations, in ecological condition, during rest and movement, with and without deep brain stimulation, once a week, between M3 and M6 post surgery.

Inclusion Criteria:Advanced disabling and drug-resistant tremorReceiving deep brain stimulation treatment with implantation of the PERCEPT™ device according to standard careChronic progressive cardiac, renal, hematological or pulmonary diseases under treatment.Patient aged between 18 to 75 yearsNormal brain MRIMATTIS score ≥ 130Subject affiliated with or benefiting from a social security planFree, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research)Exclusion Criteria:Major depressive syndrome (Beck scale > 20)MRI showing significant brain atrophy or significant hypersignalsPregnant or breastfeeding womenBeing unable to give personal consentBe subject to a measure of legal protection (curatorship, guardianship) or placed under judicial protection.