EMOTION & COGNITION IN MYOCLONUS DYSTONIA (AGENT10-ECODYST)

Background:Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood.Objective:To investigate the neural correlates of cognition and emotion in DYT-SGCE.Design:Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours.Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI.Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.

Inclusion Criteria:For all participants:Age between 15-60 yearsAble to give informed consent.For patients:An established diagnostic of DYT-SGCENo change in medication (related to DYT-SGCE) for a monthFor controls:No neurological symptomsNo medication except oral contraceptionExclusion Criteria:No deprivation of libertyInability to give a consentEstablished cognitive alterationContraindication to MRI (per MRI safety checklist)Severe chronic psychiatric illness