Neural Pressure Support, Synchrony and Respiratory Muscle Unloading

In this study patients who are intubated and on ventilator for more than 24h will be ventilated at three different level of support in Pressure Support and Neural Pressure Support to study patient-ventilator synchrony and muscle unloading.

Inclusion Criteria:-Patients intubated for more than 24 hours in the weaning phase from the ventilator.Exclusion Criteria:bleeding disorders (PK INR>1,5 or APTT>50s or platelet count <50000/µL)unstable circulation (requiring high vasopressor dose, for example Noradrenalin >0,2µg/kg/min)severe lung disease (PFI ≤ 13,3 kPa)fever> 38,5°Cpregnancy.