Defining a Vascular Phenotype of Pancreatic Ductal Adenocarcinoma With CT Perfusion Using Quantitative Radiomics

With CT perfusion it is possible to visualize the enhancement pattern of the tumor. The perfusion CT, added during the routine CECT scan will be performed at diagnosis in all patients (goal: n=125 patients) and at the first follow-up at 3 months in patients treated with systemic therapy (goal: n=50 patients). Also, we will collect histopathology of the resected tumors to perform histopathology analysis. We will correlate the CTP parameters to immunohistological findings and clinical outcome.The main goal of the study is to create an AI-assisted method to classify patients with a vascular phenotype of PDAC. We expect that we can use this phenotype to predict overall survival and chemotherapy response.

Inclusion Criteria:Clinical suspicion of pancreatic cancer18 years and olderwritten (signed and dated) informed consentExclusion Criteria:Contra-indictations to undergo CT (due to untreatable contrast allergy or renal function impairment)Previous treatment for pancreatic cancerConcomitant malignancies. Subjects with prior malignancies must be disease-free for at least 5 yearsInsufficient command of the Dutch language to be able to understand the patient information