Evaluation of the Effect of Self-Assembling Peptide P11-4

Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues.These tissues have poor regeneration capability because of the lack of both regenerative cells and vascularization.In the complex caries progression process involving dietary sugars, bacterial metabolism and demineralization, the collagenous organic matrix becomes exposed and destroyed by resident and bacterial proteases, allowing the lesion to expand

Inclusion Criteria:Patients included in the study will be required to present at least one permanent molar with an active deep carious lesion without pulpal involvement.Age of patient: 18 -30 yearsCarious lesions will be standardized by means of clinical and radiographic examinations performed before the proceduresExclusion Criteria:Teeth with deep dentinal lesions with pulpal involvement, abscess, pain or swellingDevelopmental disorders and adjacent soft tissue lesionsPatients with systemic illness will be excluded