Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation

Cervical spinal cord stimulation can elicit arm and hand movements through recruitment of proprioceptive neurons in the dorsal roots. In participants with cervical spinal cord injury, the spare roots bellow the lesion can be used to reactivate motor function. Decoding of motor intentions can be achieved through implantable electrocorticography (ECoG) devices.In this study, the investigators will use an investigational system using ECoG signal recording over the motor cortex to drive muscle specific electrical epidural spinal cord stimulation (EES). The investigators will assess the safety and preliminary efficacy of this system in 3 participants.

Must provide Informed Consent as documented by signature (Appendix Informed Consent Form),Must be at least 18 years old and no older than 75 years old at the time of enrolment,Must be suffering from non-progressive traumatic cervical spinal cord injury,Must be graded A, B, C, or D in the American Spinal Injury Association (ASIA) Impairment Scale (AIS) classification,Must be severely impaired in his upper limb function as determined by the investigator,Must have sustained the injury at least 6 months before signing the consent form,Must be able to understand and interact with the study team in French or English,Must agree to comply in good faith with all conditions of the study and to attend all scheduled appointments.Must use safe contraception for women of childbearing capacity,