Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (TCD Part)

Sex: All

Ages: 40 Years – 80 Years

Phase: NA

Enrollment: 60

Sponsor: Beijing Tiantan Hospital

Summary

This study was a single-center, exploratory, randomized controlled trial. First, the effects of ephedrine, phenylephrine, or norepinephrine on cerebral blood flow hemodynamics in patients undergoing carotid endarterectomy were evaluated using TCD techniques to investigate the specific mechanisms of the three vasopressors on cerebral blood flow and oxygen metabolism in brain tissues.

Eligibility Criteria

Inclusion Criteria:age 40-80 years.elective carotid endarterectomy.Signed informed consentExclusion Criteria:American Society of Anesthesiologists physical status classification (ASA) IV - VI.renal failure (estimated glomerular filtration rate less than 60 ml/min.m2).cardiac arrhythmias.Allergy to ephedrine, phenylephrine or norepinephrine, gadobutrol.patients with preoperative TCD suggesting poor temporal window signal.patients with severe carotid artery stenosis with no flow signal detected by TCDPatients with tandem lesions of carotid artery stenosis

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05665881). StuddyBuddy aggregates publicly available trial information.