Laryngeal Cryotherapy for Refractory Neurogenic Cough

This study aims to evaluate the safety and efficacy of upper aerodigestive tract cryotherapy treatment in patients with refractory neurogenic cough in a prospective pilot study with a validated patient reported outcome measure

Inclusion Criteria:Adult patients 18 years or older with diagnosis of neurogenic coughNeurogenic cough is a diagnosis of exclusion applied to persistent cough (8 weeks or longer)Negative workup for other causes, including sinonasal allergies/chronic sinusitis, cough-variant asthma, and GERDPatient willing to participate in a clinical trialExclusion Criteria:Uncontrolled reflux (scoring on Reflux Symptom index of 13 or higher)Vocal fold abnormalities or impairmentHistory of asthma or other underlying lung condition not adequately treated or controlledUncontrolled Allergic Rhinitis (Total Nasal Symptom Score >6, which would indicate moderate disease32)Reported symptom of postnasal dripCurrent smokerCurrent neuromodulator medication usePatient unwilling to participate in clinical trial or sign an informed consentEnd stage medical disease with poor life expectancyMedical instability deemed by the investigators as a contraindication for enrollmentAbnormal Chest X-rayAbnormal pulmonary function testing (PFTs)Positive local allergy panel (combined RAST testing)