The Role of Sugammadex in Posotoperative Urinary Retention in Patients Undergoing Pelvic Floor Reconstructive Procedures

The Investigator will perform a single-institution randomized double-blinded controlled trial comparing intraoperative Sugammadex vs. standard dose of glycopyrrolate/neostigmine combination for participants undergoing a total vaginal hysterectomy with or without pelvic organ prolapse procedures under general endotracheal anesthesia.

Inclusion Criteria:female patients undergoing a vaginal hysterectomy with the indications of pelvic organ prolapse or abnormal uterine bleedingExclusion Criteria:Patients who are already known to have voiding dysfunctionPatients who have a contraindication or intolerance to any of the drugs used in the studyHas a medical condition or surgical procedure that precludes reversal of neuromuscular block at the end of surgery.Has a neuromuscular disorder(s) that may affect neuromuscular block and/or trial assessments.Is dialysis-dependent or has severe renal insufficiency, defined as estimated creatinine clearance of <30 mL/min.Has or is suspected of having a personal history or family history (parents, grandparents, or siblings) of malignant hyperthermia.Has or is suspected of having an allergy (e.g., hypersensitivity and/or anaphylactic reaction) to study treatments or its/their excipients, to opioids/opiates, muscle relaxants or their excipients, or other medication(s) used during general anesthesia.Has received or is planned to receive toremifene within 24 hours before or within 24 hours after study medication administration.Has any condition that would contraindicate the administration of study medication.Is pregnant, is attempting to become pregnant, or is lactating.Is currently participating in or has participated in an interventional clinical trial (including any other current or ongoing trial with a sugammadex treatment arm) with an investigational compound or device within 30 days of signing the informed consent form of this current trial.Male patientsPatients undergoing a conventional laparoscopic or robotic approachPatients having a midurethral sling in addition to the vaginal hysterectomyPatients declining to participate in the studyPatients allergic to any of the drugs used in the study (sugammadex, neostigmine and/or glycopyrrolate)